Sepaskhah Mozhdeh; Mohammadi Ali; Nabavizadeh Sara Sadat; Faridi Pouya; Babaei Amir Hossein
Abstract
Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old ...
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Background: Acne vulgaris is a multi-factorial disease affecting many aspects of life. This study was conducted to compare the efficacy of fenugreek seed extract and oral azithromycin in the treatment of acne vulgaris. Methods: A total of 20 patients with acne vulgaris aged between 12 and 30 years old were entered into this 60-day, randomized, placebo-controlled, triple-blind study. The patients were randomly divided into two groups, (permuted block randomization, block size of 4), namely fenugreek and azithromycin groups. All the participants daily received two capsules containing 500 mg hydroalcoholic extract of fenugreek seeds or 125mg azithromycin, for two months. The patients were evaluated after 30 and 60 days from the start of the trial. The participants, investigators (the dermatologists who evaluated clinical responses), and statisticians who analyzed the data were blind for identity and allocation of the treatments. Results: The baseline GAGS scores in azithromycin and fenugreek groups were respectively equal to 19.66 and 23.12, and there was a reduction in both azithromycin (GAGS2=14.33) (P-value=0.019) and fenugreek extract group (GAGS2=22.75) (P-value=0.780) during the experiment. There was a statistically significant difference among the two groups (F= (2, 24) = 3.861, P=0.035). Conclusion: The effect of azithromycin was higher than fenugreek in the treatment of acne vulgaris.
Baniahmad Marjan; Ghahartars Mehdi; Aslani Fatemeh Sari; Sepaskhah Mozhdeh; Parvizi Mohammad Mahdi; Saki Nasrin; Haghighi Negin Fazelzadeh
Abstract
CLINICAL PRESENTATION A 28-year-old man referred to the dermatology clinic with an asymptomatic firm, well demarcated violaceous plaque with bumpy surface on his right medial upper shin since two years ago. At first, the lesion was an erythematous patch and gradually became like a plaque. He had pain ...
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CLINICAL PRESENTATION A 28-year-old man referred to the dermatology clinic with an asymptomatic firm, well demarcated violaceous plaque with bumpy surface on his right medial upper shin since two years ago. At first, the lesion was an erythematous patch and gradually became like a plaque. He had pain and sensation of heaviness in his leg (Figure 1). He had no other skin lesions and was otherwise healthy. There was no family history of the same skin lesion. There were no clinically significant abnormalities in laboratory evaluation. The result of serum screening for antinuclear antibodies (ANA) by ELISA was negative. The color Doppler sonography of the right leg demonstrated multiple varicose veins in the medial aspect of the right leg draining into the distal part of the right greater saphenous vein and incompetency of the right saphenofemoral junction. A punch biopsy was performed on the plaque.
Sepaskhah Mozhdeh; Maghami Zohreh
Volume 18, Issue 4 , 2015, , Pages 179-181
Abstract
Pityriasis lichenoides is an uncommon, acquired, papulosquamous disorder that exhibits various clinical presentations, including acute, chronic, and febrile ulceronecrotic Mucha- abermann forms. Pityriasis lichenoides chronica (PLC) is the chronic form of this continuum. Its treatment is challenging ...
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Pityriasis lichenoides is an uncommon, acquired, papulosquamous disorder that exhibits various clinical presentations, including acute, chronic, and febrile ulceronecrotic Mucha- abermann forms. Pityriasis lichenoides chronica (PLC) is the chronic form of this continuum. Its treatment is challenging for patients and clinicians and some cases are multidrug resistant. Today, this disorder has many treatment choices, including topical corticosteroids, topical calcineurin inhibitors, phototherapy (ultraviolet (UV) A and narrow band UVB), methotrexate, dapsone, cyclosporine and recently etanercept. In our experience, mycophenolate mofetil was effective as a new treatment for pityriasis lichenoides.